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Invitrogen™ Plexin-A1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand: Invitrogen™ PA5143746

Product Code. 17826958

€ 536.00 / 100µL

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Description

The antibody detects a 220 kDa* protein corresponding to the apparent molecular mass of Plexin-A1 on SDS-PAGE immunoblots of adult mouse brain and Cos-7 cells transfected with mouse Plexin-A1. In immunocytochemistry, this antibody co-localizes with anti-Myc in Cos-7 cells transfected with Myc-tagged mouse Plexin-A1.

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. [UniProt].

Specifications

Antigen	Plexin-A1
Classification	Polyclonal
Conjugate	Unconjugated
Gene	PLXNA1
Gene Alias	2600013D04Rik; Kiaa4053; mKIAA4053; NOV; NOVP; Plex 1; PlexA1; plexin 1; plexin A1; plexin-1; plexin-A1; PLXN1; Plxna1; RGD1560871; semaphorin receptor NOV
Host Species	Rabbit
Purification Method	Antigen affinity chromatography
Regulatory Status	RUO
Gene ID (Entrez)	18844, 362398, 5361
Content And Storage	-20°C, Avoid Freeze/Thaw Cycles
Form	Liquid

Applications	Western Blot, Immunocytochemistry
Concentration	1 mg/mL
Formulation	PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.	P70206, Q9UIW2
Gene Symbols	PLXNA1
Immunogen	Plexin-A1 synthetic peptide (coupled to carrier protein) corresponding to a region within the semaphorin domain in human Plexin-A1. This sequence is highly conserved in rat and mouse Plexin-A1, and has low homology to other Plexin family members.
Quantity	100 μL
Primary or Secondary	Primary
Target Species	Human, Mouse, Rat
Product Type	Antibody
Isotype	IgG

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Invitrogen™ Plexin-A1 Polyclonal Antibody

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