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Invitrogen™ PLSCR1 Polyclonal Antibody
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Product Code. 17751174
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Quantity:
100 μL
Unit Size:
100µL
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17751174 100 μL 100µL
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Product Code. 17751174 Supplier Invitrogen™ Supplier No. PA5119773

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Description

Rabbit Polyclonal Antibody

Positive Control: 293 cell lysates, HUVEC, human tonsil tissue. Subcellular Location: Cell membrane, Nucleus, Membrane, Cytoplasm, perinuclear region.

The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon influx of calcium into the cytosol. This movement results in plasma membrane phospholipid remodelling and surface exposure of phosphatidylserine in injured or apoptotic cells, which leads to cell death. Interferons and other cytokines induce expression of PLSCR1, implying that PLSCR1 also functions in cytokine signaling pathways. EGF stilmulation results in tyrosine phosphorylation of PLSCR1 on tyrosines 69 and 74, which allows it to interact with Shc, and thereby connecting Src kinase activation to stimulation of the EGF receptor.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PLSCR1
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene PLSCR1
Gene Accession No. O15162
Gene Alias ca(2+)-dependent phospholipid scramblase 1; Erythrocyte phospholipid scramblase; MmTRA1a; MmTRA1b; NOR1; Phospholipid scramblase 1; phospholipid scramblase 2; PL scramblase 1; Plscr1; Tra1; Tra1a; Tra1b; transplantability-associated protein 1; Tras1; Tras2
Gene Symbols PLSCR1
Host Species Rabbit
Immunogen Synthetic peptide within N-terminal human Scramblase 1.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5359
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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