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Invitrogen™ PMCA2 ATPase Polyclonal Antibody
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Product Code. 11518601
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Quantity:
100 μg
Unit Size:
100µg
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11518601 100 μg 100µg
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Product Code. 11518601 Supplier Invitrogen™ Supplier No. PA1915

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Description

Rabbit Polyclonal Antibody

PA1-915 detects calcium pump of the plasma membrane 2 (PMCA2 ATPase) from human and rat and porcine tissues and cells. PA1-915 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~127 kDa protein and an ~133 kDa protein representing PMCA2a and PMCA2b ATPase, respectively, from rat brain microsomal fractions. PA1-915 immunizing peptide corresponds to amino acid residues 5-19 from human PMCA2 ATPase protein. This sequence is completely conserved between human and rat PMCA2 ATPase.

The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PMCA2 ATPase
Applications ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene ATP2B2
Gene Accession No. P11506, Q01814
Gene Alias Atp2b2; ATPase isoform 2 Na+K+ transporting beta polypeptide 2; ATPase isoform 2, Na+K+ transporting, beta polypeptide 2; ATPase plasma membrane Ca2+ transporting 2; ATPase, Ca++ transporting, plasma membrane 2; D6Abb2e; deaf waddler; dfw; Gena300; jog; plasma membrane Ca(2+)-ATPase; plasma membrane Ca++-ATPase; plasma membrane Ca2+ pump 2; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 2; plasma membrane calcium pump; Plasma membrane calcium pump isoform 2; Plasma membrane calcium-transporting ATPase 2; PMCA2; PMCA2a; PMCA2i; Tmy; wms; wri; wriggle
Gene Symbols ATP2B2
Host Species Rabbit
Immunogen Synthetic Peptide: T(5) N S D F Y S K N Q R N E S S(19).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100625418, 24215, 491
Target Species Human, Rat, Pig
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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