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Tocris Bioscience™ Pomalidomide
GREENER_CHOICE

Cereblon binder; also TNF-α inhibitor and antiangiogenic

Brand:  Tocris Bioscience™ 6302/10

Encompass

Product Code. 15746399

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Description

Description

Pomalidomide is a potent TNF-α inhibitor (IC50 = 13 nM). Also potently inhibits IL-2 (EC50 = 8 nM). Thalidomide derivative. Binds cereblon and inhibits its ubiquitination. Exhibits antiproliferative effects in a Namalwa lymphoma cell line. Antiangiogenic. Promotes degradation of transcription factor SALL4.
Specifications

Specifications

4-Amino-2-(2,6-dioxo-3-piperidinyl)-1 H-isoindole-1,3(2 H)-dione
19171-19-8
>98%
10 mg
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