Invitrogen™ PPP1R12B Polyclonal Antibody

Description

Immunogen sequence: TFSRSRAERQ AQEQPREKPT DTEGLEGSPE KHEPSAVPAT EAGEGQQPWG RSLDEEPICH RLRCPAQPDK PTTPASPSTS RPSLYTSSHL LWTNRFSVPD SESSETTTNT TTAKEMDKNE NEEADLDEQS SKRLSIRERR RPKERRRGTG INFWTKDEDE TDGSEEVKET WHERLSRLES GGSNPTTSDS YGDRASARAR REAREARLAT LTSRVEEDSN RDYKKLYESA LTENQKLKTK LQEAQLELAD IKSKLEKVAQ QKQEKTSDRS S.

Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome.