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PPP4C Monoclonal Antibody (OTI2H8), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA810212
This item is not returnable.
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Description
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase.Specifications
| PPP4C | |
| Monoclonal | |
| Unconjugated | |
| PPP4C | |
| PP-X, PP4, PP4C, PPH3, PPP4, PPX | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 5531 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| OTI2H8 | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| P60510 | |
| PPP4C | |
| Full length human recombit protein of human PPP4C produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG2b |
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