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Invitrogen™ Progerin Monoclonal Antibody (13A4D4)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA518073
This item is not returnable.
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Description
This antibody specifically recognizes Progerin (Lamin A delta50) and does not cross-react with endogenous prelamin A. Western blot results show a band at approximately 70 kDa.
Progerin is a 614 amino acid protein involved in Hutchinson-Gilford progeria syndrome. Progerin is most often generated by a point mutation (C1824T) in the LMNA gene that codes for lamin-A/C. This mutation activates a cryptic splice site and gives rise to a form of lamin A with a 50-amino acid internal deletion within the C-terminal domain of the protein. Approximately 80% of Hutchinson-Gilford progeria syndrome cases carry a single copy of the most common mutation, a silent point mutation, G608G (GGC > GGT), within exon 11 of the LMNA gene.
Specifications
| Progerin | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.1% sodium azide | |
| P02545 | |
| LMNA | |
| Synthetic peptide conjugated to KLH derived from within residues 604-611 (GAQSPQNC) at the C terminus of Human Progerin. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry | |
| 13A4D4 | |
| Unconjugated | |
| LMNA | |
| 70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A/C; lamin A/C-like 1; Lamin AC; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; Mutant lamin A/C; Prelamin-A/C; PRO1; progerin mutant; Renal carcinoma antigen NY-REN-32 | |
| Mouse | |
| Protein G | |
| RUO | |
| 4000 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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