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Invitrogen™ Protein APC Polyclonal Antibody
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Product Code. 16569051
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Quantity:
100 μL
Unit Size:
100µL
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16569051 100 μL 100µL
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Product Code. 16569051 Supplier Invitrogen™ Supplier No. PA596213

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: QSKENQVSAK GTWRKIKENE FSPTNSTSQT VSSGATNGAE SKTLIYQMAP AVSKTEDVWV RIEDCPINNP RSGRSPTGNT PPVIDSVSEK ANPNIKDSKD NQAKQNVGNG SVPMRTVGLE NRLNSFIQVD APDQKGTEIK PGQNNPVPVS ETNESSIVER T Positive Samples: HeLa; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, adherens junction, cytoskeleton, lamellipodium, ruffle membrane.

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Protein APC
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 1.99 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Apc
Gene Accession No. P25054, P70478, Q61315
Gene Alias adenomatosis polyposis coli; adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli; adenomatous polyposis coli protein; AI047805; APC; APC, WNT signaling pathway regulator; AU020952; AW124434; BTPS2; CC1; Deleted in polyposis 2.5; DP2; DP2.5; DP3; FAP; FPC; GS; mAPC; Min; multiple intestinal neoplasia; PPP1R46; Protein APC; protein phosphatase 1, regulatory subunit 46; RATAPC; truncated adenomatosis polyposis coli; WNT signaling pathway regulator
Gene Symbols Apc
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 2600-2760 of human APC (NP_0000292).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11789, 24205, 324
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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