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Invitrogen™ Protein C Polyclonal Antibody
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Product Code. 16567521
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Quantity:
100 μL
Unit Size:
100µL
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16567521 100 μL 100µL
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Product Code. 16567521 Supplier Invitrogen™ Supplier No. PA589751

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Description

Rabbit Polyclonal Antibody

Positive Samples: ES-2; Cellular Location: Endoplasmic reticulum, Golgi apparatus Immunogen sequence: ANSFLEELRH SSLERECIEE ICDFEEAKEI FQNVDDTLAF WSKHVDGDQC LVLPLEHPCA SLCCGHGTCI DGIGSFSCDC RSGWEGRFCQ REVSFLNCSL DNGGCTHYCL EEVGWRRCSC APGYKLGDDL LQCHPAVKFP CGRPWKRMEK KRSHLKRDTE DQEDQVDPRL IDGKMTRRGD SPWQVVLLDS KKKLACGAVL IHPSWVLTAA HCMDESKKLL VRLGEYDLRR WEKWELDLDI KEVFVHPNYS KSTTDNDI.

Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3 ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3 μg/mL. Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Protein C
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.98 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PROC
Gene Accession No. P04070, P33587
Gene Alias Activation peptide; Anticoagulant protein C; APC; autoprothrombin IIA; Blood coagulation factor XIV; EDQVDPRLIDGK; inactivator of coagulation factors Va, VIII; PC; prepro-protein C; Proc; PROC1; protein C; protein C (inactivator of coagulation factors Va and VIIIa); protein C prepropeptide; protein C, inactivator of coagulation factors Va and VIIIa; THPH3; THPH4; type I protein C; vitamin K-dependent protein C; Vitamin K-dependent protein C heavy chain; Vitamin K-dependent protein C light chain
Gene Symbols PROC
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 43-300 of human Coagulation Protein C (NP_0003031).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19123, 5624
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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