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LIME1 Monoclonal Antibody (OTI7A9), TrueMAB™, OriGene

Product Code. 17548313
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30 μL
100 μL
Unit Size:
100µL
30µL
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17548313 100 μL 100µL
17568313 30 μL 30µL
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Product Code. 17548313 Supplier Origene Technologies Supplier No. TA807654

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Description

Mouse Monoclonal Antibody

LIME (Lck-interacting molecule) is a 30 kDa double-palmitoylated protein with unusually basic cytoplasmic domain, expressed by T cells. After ligation of CD4 or CD8 T cell coreceptors, LIME is phosphorylated by Src-family kinases and associates with Lck and Fyn kinases and with their negative regulator Csk. Interestingly, Csk-mediated phosphorylation of C-terminal negative-regulatory tyrosine of LIME-associated Lck can result in increase of enzymatic activity compared with the total pool of Lck, thus, LIME serves as a positive regulator of TCR-dependent T cell signaling. However, under some circumstances, LIME may mediate inhibitory signals.

Specifications

Antigen LIME1
Applications Western Blot
Classification Monoclonal
Clone OTI7A9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene LIME1
Gene Accession No. Q9H400
Gene Alias LIME, dJ583P15.4
Gene Symbols LIME1
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 30-295 of human LIME1 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54923
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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