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Invitrogen™ PSEN2 Polyclonal Antibody
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Product Code. 17258573 Shop All Thermo Scientific Products
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Quantity:
100 μL
Unit Size:
100µL
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17258573 100 μL 100µL
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Product Code. 17258573 Supplier Invitrogen™ Supplier No. PA5115793

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Presenilin 2.

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PSEN2
Applications Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene PSEN2
Gene Accession No. O88777, P49810, Q61144
Gene Alias AD3L; AD3LP; AD4; Ad4h; AD5; Alg3; ALG-3; Alzheimer disease 4; CMD1V; E5-1; presenilin 2; presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS2; Ps-2; PSEN 2; PSEN2; Psnl2; STM2; STM-2
Gene Symbols PSEN2
Host Species Rabbit
Immunogen A synthesized peptide derived from human PSEN2(Accession P49810), corresponding to amino acid residues K306-E356.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19165, 5664, 81751
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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