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PSMC3 Monoclonal Antibody (OTI8G10), TrueMAB™, OriGene

Product Code. 17562781
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17562781 100 μL 100µL
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Product Code. 17562781 Supplier Origene Technologies Supplier No. TA500925

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Description

Mouse Monoclonal Antibody

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

Specifications

Antigen PSMC3
Applications Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
Classification Monoclonal
Clone OTI8G10
Concentration 0.97 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene PSMC3
Gene Accession No. P17980
Gene Alias TBP1
Gene Symbols PSMC3
Host Species Mouse
Immunogen Full length human recombit protein of human PSMC3 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5702
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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