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Invitrogen™ PTGR2 Polyclonal Antibody
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Product Code. 15799470 Shop All Thermo Scientific Products
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100 μL
Unit Size:
100µL
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15799470 100 μL 100µL
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Product Code. 15799470 Supplier Invitrogen™ Supplier No. PA551518

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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VAGKIGHFLG CSRVVGICGT HEKCILLTSE LGFDAAINYK KDNVAEQLRE SCPAGVDVYF DNVGGNISDT VISQMNENSH IILCGQISQY NKDVPYPPPL SPAIEAIQKE RNITRERFLV LNYKDKFEPG ILQLSQWFKE Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 87%.

ZADH1 (zinc binding alcohol dehydrogenase, domain containing 1), also known as PTGR2 (prostaglandin reductase 2), PGR2 or 15-oxoprostaglandin 13-reductase, is a 351 amino acid cytoplasmic protein that belongs to the NADP-dependent oxidoreductase L4BD family. Functioning as s a 15-oxoprostaglandin 13-reductase, ZADH1 catalyzes the conversion of 15-keto-prostaglandin E2 to 15-keto-13, 14-dihydro-prostaglandin E2 in a NADPH-dependent manner. ZADH1 overexpression has been found to repress PPAR gamma transcriptional activity and adipocyte differentiation. Widely expressed, ZADH1 is found at highest levels in heart, kidney, liver, pancreas and prostate, with moderate levels found in brain, small intestine, lung, testis and skeletal muscle. ZADH1 exists as a monomer, utilizes NADPH as a cofactor, and undergoes alternative splicing to produce two isoforms that are encoded by a gene located on human chromosome 14q24.3.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PTGR2
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PTGR2
Gene Accession No. Q8N8N7
Gene Alias 15-oxoprostaglandin 13-reductase; 15-oxoprostaglandin 13-reductase {ECO:0000250; 15-oxoprostaglandin-delta13-reductase; 1810016I24Rik; 9130222H03Rik; 9630002F03Rik; AI838763; B830026H24Rik; epididymis secretory protein Li 298; HEL-S-298; PGR2; PGR-2; PRG2; PRG-2; PRG-2 {ECO:0000250; prostaglandin reductase 2; prostaglandin reductase 2 {ECO:0000250; PTGR2; ptgr2 {ECO:0000250; UniProtKB:Q8VDQ1}; ZADH1; zinc binding alcohol dehydrogenase, domain containing 1; zinc-binding alcohol dehydrogenase domain-containing protein 1
Gene Symbols PTGR2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PTGR2. Recombinant protein control fragment (Product #RP-88892).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 145482
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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