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Invitrogen™ PUMA delta/gamma Polyclonal Antibody
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Product Code. 17147618 Shop All Thermo Scientific Products
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200 μL
Unit Size:
200µL
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17147618 200 μL 200µL
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Product Code. 17147618 Supplier Invitrogen™ Supplier No. PA5116382

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Description

Rabbit Polyclonal Antibody

PUMA delta/gamma Polyclonal Antibody for Western Blot

PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
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Specifications

Antigen PUMA delta/gamma
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene BBC3
Gene Accession No. Q9BXH1
Gene Alias BBC3; BCL2 binding component 3; Bcl-2 binding component 3; bcl-2-binding component 3; Bcl-2-binding component 3, isoforms 1/2; Bcl-2-binding component 3, isoforms 3/4; BH3-only; JFY1; JFY-1; p53 up-regulated modulator of apoptosis; PUMA; PUMA/JFY1
Gene Symbols BBC3
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 158-192 amino acids from human BBC3.
Purification Method Antigen affinity chromatography, Protein A
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27113
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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