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AKT1 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Product Code. 16152610
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Quantity:
100 μg
Unit Size:
100µg
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16152610 100 μg 100µg
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Product Code. 16152610 Supplier Abnova Supplier No. PAB18078.100ug

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Description

Rabbit polyclonal antibody raised against synthetic peptide of AKT1.

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq

Specifications

Antigen AKT1
Applications ELISA, Immunohistochemistry, Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of AKT1.
Dilution Western Blot (1:500∼1:1000) Immunohistochemistry (1:50∼1:100) ELISA(1:40000) The optimal working dilution should be determined by the end user.
Formulation In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Gene AKT1
Gene Accession No. P31749
Gene Alias AKT/MGC99656/PKB/PKB-ALPHA/PRKBA/RAC/RAC-ALPHA
Gene Symbols AKT1
Host Species Rabbit
Immunogen A synthetic peptide corresponding to residues surrounding Y312, Y315 and Y316 of human AKT1.
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 207
Test Specificity This antibody is specific to AKT1/2/3.
Target Species Human, Mouse, Rat
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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