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ALK Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of ALK.

Brand:  Abnova PAB18082.100ug

Product Code. 16192610

  • € 403.00 / 100µg

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This item is not returnable. View return policy

Description

Description

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. [provided by RefSeq]

Specifications

Specifications

ALK
Polyclonal
Rabbit polyclonal antibody raised against synthetic peptide of ALK.
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Q9UM73
ALK
A synthetic peptide corresponding to human ALK.
RUO
238
Human, Mouse
Liquid
ELISA, Immunohistochemistry, Immunohistochemistry (PFA fixed)
Unconjugated
Immunohistochemistry (1:50∼1:100) ELISA (1:40000) The optimal working dilution should be determined by the end user.
ALK
CD246/Ki-1/TFG/ALK
Rabbit
100 μg
Primary
This antibody is specific to ALK.
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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