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AR Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of AR.

Brand:  Abnova PAB24795.100uL

Product Code. 16045017

  • € 503.00 / 100µL

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Description

Description

The androgen receptor gene is more than 90kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq

Specifications

Specifications

AR
Polyclonal
Unconjugated
Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:200) The optimal working dilution should be determined by the end user.
AR
AR
A synthetic peptide corresponding to AR.
100 μL
Primary
AR polyclonal antibody detects endogenous levels of AR protein.
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Immunohistochemistry (PFA fixed), Western Blot
1 mg/mL
Rabbit polyclonal antibody raised against synthetic peptide of AR.
In PBS, pH 7.2 (0.05% sodium azide)
AIS/DHTR/HUMARA/KD/NR3C4/SBMA/SMAX1/TFM
Rabbit
Antigen affinity purification
RUO
367
Human
Liquid
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