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CDKN1A Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of CDKN1A.

Brand:  Abnova PAB2922.400uL

Product Code. 16048107

  • € 388.00 / 400µL

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Description

Description

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. [provided by RefSeq

Specifications

Specifications

CDKN1A
Polyclonal
Rabbit polyclonal antibody raised against synthetic peptide of CDKN1A.
In PBS (0.09% sodium azide)
P38936
CDKN1A
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human CDKN1A.
400 μL
Primary
Human
Liquid
ELISA, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Western Blot (1:1000) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
CDKN1A
CAP20/CDKN1/CIP1/MDA-6/P21/SDI1/WAF1/p21CIP1
Rabbit
Protein G purification
RUO
1026
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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