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CYP2D6 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against recombinant CYP2D6.

Brand:  Abnova PAB28309.100uL

Product Code. 16166680

  • € 503.00 / 100µL

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Description

Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Sequence: EYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTE
Specifications

Specifications

CYP2D6
Polyclonal
Rabbit polyclonal antibody raised against recombinant CYP2D6.
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
P10635
CYP2D6
Recombinant protein corresponding to amino acids of recombinant CYP2D6.
100 μL
Primary
Human
Liquid
Immunohistochemistry, Western Blot
Unconjugated
Immunohistochemistry (1:200-1:500) The optimal working dilution should be determined by the end user.
CYP2D6
CPD6/CYP2D/CYP2D@/CYP2DL1/MGC120389/MGC120390/P450-DB1/P450C2D/P450DB1
Rabbit
Antigen affinity purification
RUO
1565
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
IgG
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