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DDR1 (phospho Y513), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human DDR1.
Brand: Abnova PAB29227.100uL
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Beschreibung
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq
Spezifikation
| DDR1 | |
| Polyclonal | |
| Rabbit polyclonal antibody raised against synthetic phosphopeptide of human DDR1. | |
| In PBS, pH 7.4 (without mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide) | |
| Q08345 | |
| DDR1 | |
| Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y513 of human DDR1. | |
| 100 μL | |
| Primary | |
| This antibody detects endogenous levels of DDR1 only when phosphorylated at tyrosine 513. | |
| Store at -20°C. Avoid repeated freezing and thawing. |
| Immunohistochemistry (PFA fixed), Western Blot | |
| Unconjugated | |
| Immunohistochemistry (1:50-1:100) Western Blot (1:500-1000) The optimal working dilution should be determined by the end user. | |
| DDR1 | |
| CAK/CD167/DDR/EDDR1/MCK10/NEP/NTRK4/PTK3/PTK3A/RTK6/TRKE | |
| Rabbit | |
| Affinity purification | |
| RUO | |
| 780 | |
| Human, Mouse, Rat | |
| Liquid |
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