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DUSP8 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of DUSP8.

Brand:  Abnova PAB4135.400uL

Product Code. 16088937

  • € 388.00 / 400µL

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Description

Description

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq

Specifications

Specifications

DUSP8
Polyclonal
Rabbit polyclonal antibody raised against synthetic peptide of DUSP8.
In PBS (0.09% sodium azide)
NP_004411
DUSP8
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human DUSP8.
400 μL
Primary
Human
Liquid
ELISA, Immunohistochemistry (PFA fixed), Western Blot
Unconjugated
ELISA (1:1000) Western Blot (1:100-500) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
DUSP8
C11orf81/FLJ42476/FLJ42958/HB5/HVH-5/HVH8
Rabbit
Protein G purification
RUO
1850
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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