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ERBB2 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of ERBB2.

Brand:  Abnova PAB18363.100ug

Product Code. 16112880

  • € 403.00 / 100µg

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Description

Description

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq

Specifications

Specifications

ERBB2
Polyclonal
Unconjugated
Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) ELISA (1:20000) The optimal working dilution should be determined by the end user.
ERBB2
CD340/HER-2/HER-2/neu/HER2/NEU/NGL/TKR1
Rabbit
Affinity purification
RUO
2064
Human
Liquid
ELISA, Immunohistochemistry (PFA fixed), Western Blot
1 mg/mL
Rabbit polyclonal antibody raised against synthetic peptide of ERBB2.
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
P04626
ERBB2
A synthetic peptide corresponding to residues surrounding T686 of human ERBB2.
100 μg
Primary
This antibody is specific to ERBB2.
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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