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ERBB3 (phospho Y1328), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of ERBB3.

Brand:  Abnova PAB12186.100uL

Product Code. 16263240

  • € 406.00 / 100µL

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Description

Description

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq

Sequence: PDYpWH
Specifications

Specifications

ERBB3
Polyclonal
Unconjugated
Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) Immunofluorescence (1:100-1:200) The optimal working dilution should be determined by the end user.
ERBB3
ErbB-3/HER3/LCCS2/MDA-BF-1/MGC88033/c-erbB-3/c-erbB3/erbB3-S/p180-ErbB3/p45-sErbB3/p85-sErbB3
Rabbit
Immunoaffinity purification
RUO
2065
Human, Mouse, Rat
Liquid
Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
1 mg/mL
Rabbit polyclonal antibody raised against synthetic phosphopeptide of ERBB3.
In PBS (without mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
P21860
ERBB3
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y1328 of human ERBB3.
100 μL
Primary
Her3/ErbB3 (phospho-Tyr1328) Antibody detects endogenous levels of Her3/ErbB3 only when phosphorylated at tyrosine 1328.
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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