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F12 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against native F12.

Brand:  Abnova PAB19872.150ug

Product Code. 16123050

  • € 388.00 / 150µg

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This item is not returnable. View return policy

Description

Description

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq

Specifications

Specifications

F12
Polyclonal
Rabbit polyclonal antibody raised against native F12.
In PBS, pH 7.5 (0.02% sodium azide, 50% glycerol (v/v))
HAE3/HAEX/HAF
Rabbit
Affinity purification
RUO
2161
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
ELISA, Western Blot
Unconjugated
The optimal working dilution should be determined by the end user.
F12
F12
Native purified F12 from human plasma.
150 μg
Primary
Human
Liquid
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