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GCK Rabbit anti-Human, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic peptide of GCK.
Brand: Abnova PAB3532.400uL
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Description
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with noninsulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq
Specifications
| GCK | |
| Polyclonal | |
| Rabbit polyclonal antibody raised against synthetic peptide of GCK. | |
| In PBS (0.09% sodium azide) | |
| P35557 | |
| GCK | |
| A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human GCK. | |
| 400 μL | |
| Primary | |
| Human | |
| Liquid |
| ELISA, Immunohistochemistry (Paraffin), Western Blot | |
| Unconjugated | |
| Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-100) Western Blot (1:1000) The optimal working dilution should be determined by the end user. | |
| GCK | |
| GK/GLK/HHF3/HK4/HKIV/HXKP/MODY2 | |
| Rabbit | |
| Protein G purification | |
| RUO | |
| 2645 | |
| Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. |
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