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ITCH, Rabbit, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ITCH.

Brand:  Abnova PAB29228.100uL

Product Code. 16264220

  • € 406.00 / 100µL

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Description

Description

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells. [provided by RefSeq

Specifications

Specifications

ITCH
Polyclonal
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human ITCH.
In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
AIF4/AIP4/NAPP1/dJ468O1.1
Rabbit
Affinity purification
RUO
83737
Human, Mouse
Liquid
Immunohistochemistry (PFA fixed)
Unconjugated
Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user.
ITCH
ITCH
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y420 of human ITCH.
100 μL
Primary
This antibody detects endogenous levels of ITCH only when phosphorylated at tyrosine 420.
Store at -20°C.
Avoid repeated freezing and thawing.
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