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MAP3K5 Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of MAP3K5.

Brand:  Abnova PAB0327.50uL

Product Code. 16038726

  • € 407.00 / 50µL

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Description

Description

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq

Sequence: CHEEQPSNQTVRRPQAVIED
Specifications

Specifications

MAP3K5
Polyclonal
Rabbit polyclonal antibody raised against synthetic peptide of MAP3K5.
In serum (0.05% sodium azide)
ASK1/MAPKKK5/MEKK5
Rabbit
50 μL
Primary
Human
Liquid
Immunohistochemistry (PFA fixed), Immunoprecipitation
Unconjugated
The optimal working dilution should be determined by the end user.
MAP3K5
MAP3K5
A synthetic peptide corresponding to amino acids 1198 to 1216 of human MAP3K5.
RUO
4217
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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