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TOP2A Rabbit anti-Human, Mouse, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of TOP2A.

Brand:  Abnova PAB26938.100uL

Product Code. 16027117

  • € 503.00 / 100µL

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Description

Description

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq

Specifications

Specifications

TOP2A
Polyclonal
Unconjugated
Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:200) The optimal working dilution should be determined by the end user.
TOP2A
TOP2A
A synthetic peptide corresponding to human TOP2A.
100 μL
Primary
TOP2A polyclonal antibody detects endogenous levels of TOP2A protein.
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Immunohistochemistry (PFA fixed), Western Blot
1 mg/mL
Rabbit polyclonal antibody raised against synthetic peptide of TOP2A.
In PBS, pH 7.2 (0.05% sodium azide)
TOP2/TP2A
Rabbit
Affinity purification
RUO
7153
Human, Mouse
Liquid
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