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Invitrogen™ RAD18 Monoclonal Antibody (2G8D12)
Mouse Monoclonal Antibody
Brand: Invitrogen™ MA538618
This item is not returnable.
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Description
This antibody has been tested in indirect ELISA.
Human Rad18 (hRad18) is homologue of the S. pombe Rad18 (3,4). In yeast, Rad6 and Rad18 play a crucial role in post-replication repair functions in gap-filling of a daughter strand on replication of damaged DNA (2). Furthermore, Rad6-Rad18 interaction is thought to be critical at an early step during lesion bypass in yeast. In vivo, Rad18 protein forms a tight complex with Rad6 through a conserved ring-finger motif (3,4). It has been suggested that Rad18-Rad6 complex binds to the damaged sites by the single-stranded DNA binding property of Rad 18. This is followed by degradation of the stalled components of DNA replication by ubiquitin-conjugating enzyme activity of Rad6 (1). The human Rad18 maps on chromosome 3p24-25, the region which is often deleted in lung, breast, ovary, and testis cancers. The human RAD18 gene codes for a protein of 495 amino acids with a predicted molecular weight of 56 kDa. The human Rad18 is ubiquitously expressed in various human tissues.
Specifications
| RAD18 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 0.05% sodium azide | |
| Q9NS91 | |
| Rad18 | |
| Purified recombinant fragment of human RAD18 (aa: 332-430) expressed in E. Coli. | |
| 100 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| ELISA, Flow Cytometry, Western Blot | |
| 2G8D12 | |
| Unconjugated | |
| Rad18 | |
| 2810024C04Rik; E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; mRAD18Sc; postreplication repair protein hRAD18p; postreplication repair protein RAD18; post-replication repair protein RAD18SC; Rad18; RAD18 E3 ubiquitin protein ligase; RAD18 homolog; RAD18 homolog (S. cerevisiae); RAD18, E3 ubiquitin protein ligase; RAD18, S. cerevisiae, homolog; Rad18sc; RING finger protein 73; RING-type E3 ubiquitin transferase RAD18; RNF73 | |
| Mouse | |
| Protein G | |
| RUO | |
| 56852 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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