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Invitrogen™ RADIL Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA562479
Description
Immunogen sequence: YGTHFIMSPP TKSKLKRQSQ LLSSMLSRTL SYKYRDLDST FSSLGASDDP AELSTQLSAP GVLKVFGDSV CTGTHYKSVL A Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 95%.
Radil is a broadly expressed adapter protein that contains a RA-like domain, a PDZ domain and a DIL domain. Like RAPL and RIAM, Radil interacts preferentially with active GTP-bound Rap1, and overexpression of Radil enhances integrin-mediated adhesion. In addition, Radil knock down inhibits cell-substrate adhesion in HT1080, AD293, and NMuMG cells and results in migration defects in SW1353 and zebrafish neural crest cells. Radil regulates neutrophil adhesion by specifically enhancing beta2-integrin activation, as well as focal adhesion kinase (FAK) and paxillin phosphorylation.
Specifications
| RADIL | |
| Polyclonal | |
| Unconjugated | |
| RADIL | |
| AI536456; D930005D10Rik; KIAA1849; Radil; Rap associating with DIL domain; Rap GTPase interactor; Ras association and DIL domains; ras-associating and dilute domain-containing protein; RASIP2 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 55698 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunocytochemistry | |
| 0.2 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q96JH8 | |
| RADIL | |
| Recombinant protein corresponding to Human RADIL. Recombinant protein control fragment (Product #RP-101382). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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