Invitrogen™ RANBP3 Recombinant Rabbit Monoclonal Antibody (B24H15L41)

Description

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Ran binding protein 3 (RanBP3) is a member of Ran GTPase binding proteins that is located at the nuclear pore complex (NPC) and plays an essential role in the transport between cytoplasm and nucleus. RANPB3 is expessed as two spliced forms, RanBP3a and RanBP3b, both of which contains two FXFG motifs, characteristic of a subgroup of nucleoporins in addition to nuclear localization signal in the amino-terminal region (amino acid residues 40-57) and a unique acidic carboxyl terminus which is integral to its switch function.