Invitrogen™ RAP Polyclonal Antibody

Description

Immunogen sequence: RMEKLNQLWE KAQRLHLPPV RLAELHADLK IQERDELAWK KLKLDGLDED GEKEARLIRN LNVILAKYGL DGKKDARQVT SNSLSGTQED GLDDPRLEKL WHKAKTSGKF SGEELDKLWR EFLHHKEK Highest antigen sequence indentity to the following orthologs: Mouse - 81%, Rat - 80%.

The term RAP typically refers to receptor-associated protein, encoded by the LRPAP1 gene, which plays a significant role in the trafficking and function of certain receptors within cells. RAP is primarily involved in the regulation of low-density lipoprotein receptor-related proteins (LRPs) by acting as a chaperone during protein transport within the endoplasmic reticulum (ER). It prevents premature ligand binding and assists in the proper folding and assembly of receptor complexes, ensuring efficient receptor function and trafficking to the cell surface. RAP also influences cellular processes related to cholesterol metabolism and cell signaling through its interactions with these receptors. Its function is crucial for transporting and recycling receptors involved in various pathways, including lipid metabolism, endocytosis, and cellular homeostasis. Dysregulation of RAP or related receptor functions can impact metabolic health and are implicated in conditions such as atherosclerosis, neurodegenerative disorders, and cancer.