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Invitrogen™ RAP Recombinant Rabbit Monoclonal Antibody (4)

Product Code. 16323464
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
16323464 100 μL 100µL
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Product Code. 16323464 Supplier Invitrogen™ Supplier No. MA529399

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Description

Rabbit Recombinant Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for Human LRPAP1/A2MRAP.

The term RAP typically refers to receptor-associated protein, encoded by the LRPAP1 gene, which plays a significant role in the trafficking and function of certain receptors within cells. RAP is primarily involved in the regulation of low-density lipoprotein receptor-related proteins (LRPs) by acting as a chaperone during protein transport within the endoplasmic reticulum (ER). It prevents premature ligand binding and assists in the proper folding and assembly of receptor complexes, ensuring efficient receptor function and trafficking to the cell surface. RAP also influences cellular processes related to cholesterol metabolism and cell signaling through its interactions with these receptors. Its function is crucial for transporting and recycling receptors involved in various pathways, including lipid metabolism, endocytosis, and cellular homeostasis. Dysregulation of RAP or related receptor functions can impact metabolic health and are implicated in conditions such as atherosclerosis, neurodegenerative disorders, and cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RAP
Applications ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Lrpap1
Gene Accession No. P30533
Gene Alias 39 kDa receptor-associated protein; A2MRAP; A2RAP; AA617339; AI790446; Alpha-2-macroglobulin receptor-associated protein; Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin binding protein-44) (HBP-44); alpha-2-MRAP; AU042172; C77774; gp330-binding 45 kDa protein; HBP44; HBP-44; heparin-binding protein 44; LDL receptor related protein associated protein 1; low density lipoprotein receptor related protein, associated protein 1; low density lipoprotein receptor-related protein associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1); Lrpap1; MRAP; MYP23; RAP
Gene Symbols Lrpap1
Host Species Rabbit
Immunogen Recombinant Human LRPAP1 protein (Tyr35-Leu357).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4043
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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