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Description
The T21 monoclonal antibody specifically binds to CD125 which is also known as the alpha subunit of the IL-5 Receptor (IL5RA/IL-5R α ). CD125 is a type I transmembrane protein that belongs to the hemopoietin receptor and Ig gene superfamilies. It is expressed on B cells and eosinophils. CD125 associates with the Common β chain ( β c/Bc) subunit, also known as CD131, to form the functional IL-5 Receptor complex. Mouse IL-5 belongs to the hematopoietic growth factor family of cytokines and promotes the growth and differentiation of B cells and eosinophils. Upon binding, the T21 antibody blocks IL-5 binding to its receptor and can inhibit IL-5 induced B-cell proliferation and antibody production.
Specifications
| CD125 | |
| Monoclonal | |
| 0.2mg/mL | |
| Il5r; Il5ra; IL-5RA; IL-5Rα; IL-5R-alpha; IL-5R subunit alpha | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Mouse | |
| IgG1 λ |
| Flow Cytometry | |
| T21 | |
| Brilliant Violet 605 | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Mouse T88-M Cell Line | |
| 50 μg | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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