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Description
The 7E.17G9 monoclonal antibody specifically binds to CD278, the I nducible Cos timulatory molecule (ICOS), a 47-57 kDa homodimeric glycoprotein of the CD28 family of costimulatory molecules. ICOS is expressed on subpopulations of CD4-CD8- and CD4+CD8- (but not CD4-CD8+ or CD4+CD8+) thymocytes, on some T-cell lines, and on small numbers of peripheral leukocytes. It is upregulated on T lymphocytes following activation via the T-cell receptor. The T-cell activation marker H4 is the same molecule as ICOS. ICOS is a costimulatory receptor, and its ligand on antigen-presenting cells has been called B7RP-1, GL50, B7h, B7-H2, or LICOS. There is considerable evidence that the interaction of ICOS with its ligand is involved in the regulation of many, but not all, T-cell-mediated immune responses.
Specifications
| CD278 | |
| Monoclonal | |
| 0.2mg/mL | |
| ICOS; Ailim; CCLP; CRP-1; Ly115; Inducible T-cell costimulator | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Mouse | |
| IgG2b κ |
| Flow Cytometry | |
| 7E.17G9 | |
| Brilliant Violet 711 | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Mouse Icos cDNA and ICOS hexahistidine fusion protein | |
| 50 μg | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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