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Description
The 9C10 (MFR4.B) monoclonal antibody specifically binds to the Integrin α 4 chain (CD49d), which is expressed as a heterodimer with either of two β chains, β 1 or β 7. The α 4β 1 integrin (VLA-4, CD49d/CD29) is expressed on most peripheral lymphocytes, thymocytes, and monocytes; while the α β 7 also preferentially binds to the mucosal vascular addressin, MAdCAM-1. Although the 9C10 (MFR4.B) antibody alone has been reported to have little function-blocking activity, it can augment the inhibitory effects of mAb R1-2 (Cat. No. 553153), resulting in almost complete inhibition of VLA-4 binding to VCAM-1.
The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50-nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates.
Spécification
| CD49d | |
| Monoclonal | |
| 0.2mg/mL | |
| Integrin α4; Itga4; Integrin alpha-4; LPAM alpha; VLA-4 alpha; VLA-4a | |
| Rat | |
| Affinity Purified | |
| RUO | |
| Mouse | |
| IgG2a κ |
| Flow Cytometry | |
| 9C10(MFR4.B) | |
| Brilliant Violet 421 | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Mouse (C57BL/6xA/J)F[1] Fetal Liver Mast MC/9 | |
| 50 μg | |
| Primary | |
| Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. |
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Nom du produit
For Research Use Only
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