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XRCC5, Rat, Polyclonal Antibody, Abnova™
Description
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by nonhomologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq
Specifications
Specifications
| Antigen | XRCC5 |
| Applications | Immunohistochemistry, Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of XRCC5. |
| Dilution | Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:200) The optimal working dilution should be determined by the end user. |
| Formulation | In PBS, pH 7.2 (0.09% sodium azide) |
| Gene | XRCC5 |
| Gene Alias | FLJ39089/KARP-1/KARP1/KU80/KUB2/Ku86/NFIV |
| Gene Symbols | XRCC5 |
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