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Invitrogen™ RBL1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA584228
This item is not returnable.
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Description
Immunogen sequence: ESLAWSHDSA LWEALQVSAN KVPTCEEVIF PNNFETGNGG NVQGHLPLMP MSPLMHPRVK EVRTDSGSLR RDMQPLSPIS VHER Highest antigen sequence indentity to the following orthologs: Mouse - 86%, Rat - 86%.
RB-like 1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and RB-like 1 can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that RB-like 1 may also be a tumor suppressor.
Specifications
| RBL1 | |
| Polyclonal | |
| Unconjugated | |
| RBL1 | |
| 107 kDa retinoblastoma-associated protein; AW547426; CP107; DNA-binding protein RFX5; MGC40006; p107; pRb1; RB transcriptional corepressor like 1; Rbl1; Regulatory factor X 5; regulatory factor X, 5 (influences HLA class II expression); regulatory factor X5; retinoblastoma-like 1; retinoblastoma-like 1 (p107); retinoblastoma-like protein 1; RFX5 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 5933 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot | |
| 0.2 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| P28749 | |
| RBL1 | |
| Recombinant protein corresponding to Human RBL1. Recombinant protein control fragment (Product #RP-95260). | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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