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Invitrogen™ RC3H1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA585598
This item is not returnable.
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Description
Keep as concentrated solution. Predicted reactivity: Mouse (91%). Positive Control: 293T, A431, HeLa, HepG2, 3xFlag-human RC3H1 transfected 293T. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
Specifications
| RC3H1 | |
| Polyclonal | |
| Unconjugated | |
| RC3H1 | |
| 5730557L09Rik; Gm551; Kiaa2025; mKIAA2025; N28103; probable E3 ubiquitin-protein ligase Roquin; protein Sanroque; RC3H1; RGD1563512; RING CCCH (C3H) domains 1; RING finger and C3H zinc finger protein 1; ring finger and CCCH-type domains 1; RING finger and CCCH-type zinc finger domain-containing protein 1; ring finger and CCCH-type zinc finger domains 1; RING finger protein 198; RNF198; ROQUIN; Roquin-1 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 149041 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Western Blot | |
| 1 mg/mL | |
| PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
| Q5TC82 | |
| RC3H1 | |
| Recombinant protein encompassing a sequence within the C-terminus region of human RC3H1. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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