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R&D Systems™ Recombinant Human NCAM-1/CD56 Fc Chimera Protein

Product Code. 18767136
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Quantity:
50 μg
Unit Size:
50µg
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Product Code. 18767136

Brand: R&D Systems™ 10136NC050

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This item is not returnable. View return policy

Description

Neural cell adhesion molecule 1 (NCAM-1), also known as CD56, is a multifunctional member of the Ig superfamily

  • It belongs to a family of membrane-bound glycoproteins that are involved in Ca++ independent cell matrix and homophilic or heterophilic cell-cell interactions.
  • NCAM-1 in the adult brain shows a decline of sialylation relative to earlier developmental periods.
  • In regions that retain a high degree of neuronal plasticity, however, the adult brain continues to express polysialylated-NCAM-1, suggesting sialylation of NCAM-1 is involved in regenerative processes and synaptic plasticity
  • NCAM can function as a receptor for GDNF family of ligands. GDNF stimulates Schwann cell migration and neurite outgrowth in hippocampal and cortical neurons through binding to NCAM-1 and activation of Fyn, independently of RET
  • NCAM-1 also interacts with Ig IIIC isoform of the FGFR1 and plays an important role in developmental events as well as tumor progression
  • Due to expression on immune cells NCAM-1 has great implications on tumor progression, infection, and disease development
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P13591-1
For Use With (Application) Bioactivity
Gene ID (Entrez) 4684
Molecular Weight (g/mol) 103 kDa
Purification Method >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining
Quantity 50 μg
Source

Human embryonic kidney cell, HEK293-derived human NCAM-1/CD56 protein

Human NCAM-1/CD56 (Leu20-Gly708) Accession # P13591-1IEGRMDHuman IgG1 (Pro100-Lys330)N-terminus C-terminus
Storage Requirements Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 2 weeks, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
Endotoxin Concentration <0.10 EU per 1 μg of the protein by the LAL method
Conjugate Unconjugated
Reconstitution Reconstitute at 500 μg/mL in PBS
Buffer Lyophilized from a 0.2 μm filtered solution in PBS
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