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R&D Systems™ Recombinant Mouse OLT-2/TARM1 Fc Chimera Protein

Product Code. 18749306
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Quantity:
50 μg
Unit Size:
50µg
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Product Code. 18749306

Brand: R&D Systems™ 10000TA050

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This item is not returnable. View return policy

Description

The Recombinant Mouse OLT-2/TARM1 Fc Chimera Protein is derived from NS0

  • TARM-1 (T cell interacting, activating receptor on myeloid cells-1), also name OLT-2 (OSCAR-like Transcript 2), is a type 1 membrane protein expressed by neutrophils, inflammatory monocytes, macrophages, and dendritic cells.
  • Mature mouse TARM-1 contains a 242 amino acid (aa) long extracellular domain with two Ig-like C2 domains, a 21 aa long transmembrane domain and a 9 aa long cytoplasmic domain.
  • The extracellular domain of mouse TARM-1 shares 81.6% and 46.5% aa identity with rat and human TARM-1 respectively.
  • TARM-1 associates with the ITAM bearing adaptor FcR gamma, but not with DAP10 or DAP12.
  • TARM1 expression is also up-regulated by bone marrow-derived macrophages and dendritic cells following stimulation with TLR agonists in vitro.
  • TARM1 receptor stimulation on macrophages and neutrophils co-stimulate the secretion of proinflammatory cytokines induced by TLR ligands, such as LPS.
  • TARM1 Fc fusion protein inhibits anti-CD3 induced CD4 + cell activation, suggesting that TARM1 ectodomain interacts with an unidentified receptor on T cells to inhibit T cell activation.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number B6A8R8
For Use With (Application) Bioactivity
Gene ID (Entrez) 441864
Molecular Weight (g/mol) 53 kDa
Purification Method >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie™ Blue Staining
Quantity 50 μg
Source

Mouse myeloma cell line, NS0-derived mouse OLT-2/TARM1 protein

Mouse TARM-1 (Gln17-Ile257) Accession # B6A8R8IEGRMDPMouse IgG2a (Glu98-Lys330)N-terminus C-terminus
Storage Requirements Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, ≤ -20°C under sterile conditions after reconstitution.
Endotoxin Concentration <0.10 EU per 1 μg of the protein by the LAL method
Conjugate Unconjugated
Reconstitution Reconstitute at 500 μg/mL in PBS
Buffer Lyophilized from a 0.2 μm filtered solution in PBS
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