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Invitrogen™ RHD Recombinant Human Monoclonal Antibody (D7C2)
Human Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA551821
This item is not returnable.
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Description
RHD Recombinant Monoclonal Antibody for Flow, CT
The Rhesus (Rh) blood group system represents one of the most complex and important systems in humans. Two highly homologous genes RHD and RHCE (collectively referred to as RH30 or RHCED) encode the antigens of the Rh blood group system (1-4). These tightly linked genes map to human chromosomal position 1p34.1-1p36. The RHD gene, which is commonly deleted from a large segment of the population, encodes the most potent blood group immunogen, the D antigen (2,5). Rh incompatibility between maternal and fetal blood types results in hemolytic disease of the newborn (HDN), which often results in fetal death (1,2,6). The RHCE gene exists in four allelic forms, and each allele determines the expression of two antigens in Ce, ce, cE, or CE combinations (2,4,5). The RHCED antigens exist as integral membrane proteins with contain 12-transmembrane helices, and maintain erythrocyte membrane integrity. The presentation of the Rh antigenic activity requires the formation of a complex between the RHCED antigens and RHAG (RH50).
Specifications
| RHD | |
| Recombinant Monoclonal | |
| 1 mg/mL | |
| PBS with 0.02% ProClin 300 | |
| Q02161 | |
| RHD | |
| A Rh- volunteer blood donor (r/r) was injected with 5ml of Rh+ erythrocytes (R1/r) and the peripheral lymphocytes were isolated and transformed with 1 ml of culture supernatant of the EBV marmoset B96-8 cell line. | |
| 50 μg | |
| Primary | |
| Human | |
| Antibody | |
| IgM λ |
| Cytotoxicity Assay, Flow Cytometry | |
| D7C2 | |
| Unconjugated | |
| RHD | |
| blood group antigen D; blood group protein RHD; blood group Rh(D) polypeptide; CD240D; D antigen (DCS); DIIIc; Erythrocyte membrane glycoprotein Rh30; Rh; Rh blood group antigen Evans; Rh blood group D antigen; Rh blood group protein; Rh blood group, D anitgen; Rh blood group, D antigen; RH polypeptide 2; Rh30; Rh4; Rhced; RHD; RhD blood group antigen; RhD polypeptide; RhDCw; RHDel; RHDVA(TT); Rhesus blood group CE and D; Rhesus blood group D antigen allele DIII type 7; rhesus D antigen; Rhesus system D polypeptide; RhII; RhK562-II; Rhl1; Rh-like polypeptide; RhPI; RHPII; RHXIII; truncated rhesus blood group D antigen; truncated rhesus D | |
| Human | |
| Affinity chromatography | |
| RUO | |
| 6007 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
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