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Invitrogen™ Rhesus/Cynomolgus monkey TNF-alpha Recombinant Protein

Product Code. 17976381
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Quantity:
1 mg
100 μg
20 μg
Unit Size:
100µg
1mg
20µg
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Product Code. 17976381

Brand: Invitrogen™ RP87949

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This item is not returnable. View return policy

Description

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (1099 μL) be added to the vial to prepare a stock solution of 0.91 mg/mL. Concentration is measured by UV.

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P48094, P79337
For Use With (Application) Control, Bioactivity
Format Lyophilized
Formulation PBS with 5% mannitol, 5% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
Gene ID (Entrez) 102139631, 715467
Molecular Weight (g/mol) 17.4 kDa
Name Rhesus/Cynomolgus monkey TNF-alpha
pH Range 7.4
Purification Method Purified
Quantity 1 mg
Storage Requirements -20°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias APC1 protein; Cachectin; C-domain 1; C-domain 2; cTNF; DADB-70P7.1; DIF; ICD1; ICD2; Intracellular domain 1; Intracellular domain 2; N-terminal fragment; NTF; RATTNF; Tnf; TNF alpha; TNF superfamily; TNF α; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNFalpha; TNF-alpha; Tnfsf1a; TNFSF2; TNFα; TNLG1F; Tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor alpha (cachetin); tumor necrosis factor alpha precursor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor, membrane form; Tumor necrosis factor, soluble form; tumor necrosis factor-alpha; tumor necrosis factor-alpha precursor; tumor-necrosis factor; tumour necrosis factor
Common Name TNF alpha
Gene Symbol Tnf
Biological Activity Measured in a cytotoxicity assay using L-929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is typically 2-20 pg/mL
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence Rhesus/cynomolgus TNF-alpha, amino acids Val77-Leu233 (Accession # NP_001040614.1). Rhesus and cynomolgus TNF sequences are identical.
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Activity Measured in a cytotoxicity assay using L-929 mouse fibrosarcoma cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is typically 2-20 pg/mL.
Expression System E. coli
Form Lyophilized
Purity or Quality Grade >90% as determined by SDS-PAGE.
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