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Invitrogen™ Rhotekin Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA593182
This item is not returnable.
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Description
Immunogen sequence: PLCMTQPTAS GTLRVQQAGE MQNWAQVHGV LKGTNLFCYR QPEDADTGEE PLLTIAVNKE TRVRAGELDQ ALGRPFTLSI SNQYGDDEVT HTLQTESREA LQSWMEALWQ LFFDMSQWKQ CCDEIMKIET PAPRKPPQAL AKQGSLYHEM AIEPLDDIAA VTDILTQREG ARLETPPPWL AMFTDQPALP NPCSPASVAP APDWTHPLPW GRPRTFSLDA VPPDHSPRAR SVAPLPPQRS PRTRGLCSKG QPRTWLQSPV; Positive Samples: A-431, HepG2, MCF7.
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specifications
| Rhotekin | |
| Polyclonal | |
| Unconjugated | |
| RTKN | |
| hypothetical protein LOC539691; RGD:727874}; rhotekin; RTKN; rtkn {ECO:0000312; RTKN1 | |
| Rabbit | |
| Affinity Chromatography | |
| RUO | |
| 20166, 297383, 6242 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| ELISA, Western Blot, Immunocytochemistry | |
| 1.14 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q6V7V2, Q8C6B2, Q9BST9 | |
| RTKN | |
| Recombinant fusion protein containing a sequence corresponding to amino acids 254-513 of human RTKN (NP_0010150561). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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