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RNF11 Monoclonal Antibody (OTI1G7), TrueMAB™, OriGene
Mouse Monoclonal Antibody
Brand: Origene Technologies TA810976
This item is not returnable.
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Description
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates ′Lys-63′ polyubiquitin chains on RIPK1 and catalyzes the formation of ′Lys-48′-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.Specifications
| RNF11 | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with 1% BSA, 50% glycerol and 0.02% sodium azide | |
| Q9Y3C5 | |
| RNF11 | |
| Human recombit protein fragment corresponding to amino acids 2-154 of human RNF11 produced in E.coli. | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG1 |
| Western Blot | |
| OTI1G7 | |
| Unconjugated | |
| RNF11 | |
| CGI-123, SID1669 | |
| Mouse | |
| Affinity Chromatography | |
| RUO | |
| 26994 | |
| -20° C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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