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Invitrogen™ RNF169 Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA561160
This item is not returnable.
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Description
Immunogen sequence: GSGTSLEREQ FEGLGSTPDA KLDKTCISRA MKITTVNSVL PQNSVLGGVL KTKQQLKTLN HFDLTNGVLV ESLSEEPLPS LRRGRKRHCK TKHLEQ Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 74%.
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
Specifications
| RNF169 | |
| Polyclonal | |
| Unconjugated | |
| RNF169 | |
| 2900057K09Rik; E3 ubiquitin-protein ligase RNF169; KIAA1991; RING finger protein 169; RING finger protein 169; E3 ubiquitin-protein ligase RNF169; RING-type E3 ubiquitin transferase RNF169; RNF169 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 254225 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| 0.1 mg/mL | |
| PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
| Q8NCN4 | |
| RNF169 | |
| Recombinant protein fragment of Human RNF169 (Product #RP-97432) | |
| 100 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |
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