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Invitrogen™ RNF2 Recombinant Rabbit Monoclonal Antibody (24GB5455)
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Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA557696

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Product Code. 30276411

  • € 564.00 / 100µL

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Description

Description

RNF2 Recombinant Monoclonal Antibody for Western Blot, Flow

RNF2 (E3 ubiquitin-protein ligase RING2) is a ligase that mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub). Therefore, it plays a central role in histone code and gene regulation. The ligase activity is enhanced by BMI1/PCGF4. H2AK119Ub gives a specific tag for epigeneti transcriptional repression and participates in X chromosome inactivation of female mammals. RNF2 may be involved in the initiation of both imprinted and random X inactivation. RNF2 is also an essential component of a Polycomb group (PcG) multiprotein PRC1-like complex. This complex class is required to maintain the transcriptionally repressive state of many genes including Hox genes throughout development. The PcG PRC1 complex acts via chromatin remodeling and modification of histones and rendering chromatin heritably changed in its expressibility.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

RNF2
Recombinant Monoclonal
Unconjugated
RNF2
AI326319; AI450156; AU019207; BAP 1; BAP1; BAP-1; DinG; DinG protein; E3 ubiquitin-protein ligase RING2; fa19h05; GS1-120K12.1; HIP2-interacting protein 3; HIPI 3; HIPI3; Huntingtin-interacting protein 2-interacting protein 3; OTTHUMP00000060668; protein DinG; RING 1B; RING 2; RING finger protein 1B; ring finger protein 2; RING finger protein BAP-1; RING1B; RING2; RING-type E3 ubiquitin transferase RING2; RNF 2; Rnf2; wu:fa19h05; wz4556; wz4566
Rabbit
Affinity chromatography
RUO
19821, 304850, 6045
-20°C
Liquid
Flow Cytometry, Western Blot, Immunocytochemistry
24GB5455
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q4KLY4, Q99496, Q9CQJ4
RNF2
A synthesized peptide derived from human RING2 / RING1B / RNF2 (aa 118-131).
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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