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Ro 31-8220 mesylate, MedChemExpress

Product Code. 16415898
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Product Code. 16415898 Supplier Medchem Express Supplier No. HY13866

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Description

MedChemExpress Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3β (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7.

Specifications

Chemical Name or Material Ro 31-8220 mesylate
CAS 138489-18-6
Color Orange
Purity Grade Notes Research
Molecular Formula C26H27N5O5S2
Quantity 10 mg
Synonym Ro 31-8220 methanesulfonate Bisindolylmaleimide IX mesylate
Solubility Information DMSO : 35.71 mg/mL (64.50 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (insoluble)
SMILES NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N.CS(=O)(O)=O
Molecular Weight (g/mol) 553.65
Formula Weight 553.65
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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