missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 30001343

Tocris Bioscience™ Ro 31-8220 mesylate
GREENER_CHOICE

Product Code. 30001343
Click to view available options
Quantity:
10 mg
Unit Size:
10mg
This item is not returnable. View return policy

Product Code. 30001343

Brand: Tocris Bioscience™ 2002/10

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Protein kinase inhibitor

Protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na+ channels in the micromolar range. Induces protein-protein interaction between mutant SMAD4R361H and SMAD3, leading to reactivation of dormant SMAD4R361H-mediated transcriptional activity and restoration of TGF-β-induced tumor suppression activity in SMAD4 mutant cancer cells.
TRUSTED_SUSTAINABILITY

Specifications

CAS 138489-18-6
Quantity 10 mg
Molecular Formula C26H27N5O5S2
Formula Weight 553.65
Purity >97%
Molecular Weight (g/mol) 553.652
Chemical Name or Material Ro 31-8220 mesylate
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.