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Invitrogen™ RON Monoclonal Antibody (1B5A9)
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Product Code. 11355413
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Quantity:
100 μL
Unit Size:
100µL
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Product Code. Quantity unitSize
11355413 100 μL 100µL
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Product Code. 11355413 Supplier Invitrogen™ Supplier No. MA515441

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Description

Mouse Monoclonal Antibody

MA5-15441 targets RON in indirect ELISA, WB applications and shows reactivity with Human samples. The MA5-15441 immunogen is purified recombinant fragment of human RON (aa210-320) expressed in E. Coli. MA5-15441 detects RON which has a predicted molecular weight of approximately 152kDa.

MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uteru.
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Specifications

Antigen RON
Applications ELISA, Western Blot
Classification Monoclonal
Clone 1B5A9
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene MST1R
Gene Accession No. Q04912
Gene Alias CD136; Cdw136; c-met-related tyrosine kinase; friend virus susceptibility 2; Fv2; Fv-2; macrophage stimulating 1 receptor; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); macrophage-stimulating protein receptor; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MSP receptor; Mst1r; MST1R variant RON30; MST1R variant RON62; p185-Ron; protein tyrosine kinase 8; Protein-tyrosine kinase 8; PTK8; PTK8 protein tyrosine kinase 8; receptor protein tyrosine kinase, c-met-related; RON; RON variant E2E3; Stem cell-derived tyrosine kinase; STK
Gene Symbols MST1R
Host Species Mouse
Immunogen Purified recombinant fragment of human RON (aa210-320) expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4486
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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